Clasto-Lactacystin β-lactone

Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

Product Specifications

CAS Number

[154226-60-5]

Product Name Alternative

Omuralide; β-Clastolactacystin

UNSPSC

12352005

Hazard Statement

H319

Target

Proteasome

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Clasto-Lactacystin__beta_-lactone.html

Concentration

2.34 mM * 100 μL in Methyl acetate

Purity

99.9

Solubility

10 mM in DMSO

Smiles

O=C([C@H](C)[C@]1([H])O2)N[C@@]1([C@@H](O)C(C)C)C2=O

Molecular Formula

C10H15NO4

Molecular Weight

213.23

Precautions

H319

References & Citations

[1]Fenteany G, et al. A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A. 1994 Apr 12;91 (8) :3358-62.|[2]McCormack TA, et al. Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone. Biochemistry. 1998 May 26;37 (21) :7792-800.