Clasto-Lactacystin β-lactone
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
Product Specifications
CAS Number
154226-60-5
Product Name Alternative
Omuralide; β-Clastolactacystin
UNSPSC
12352005
Hazard Statement
H319
Target
Proteasome
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Clasto-Lactacystin__beta_-lactone.html
Concentration
2.34 mM * 100 μL in Methyl acetate
Purity
99.9
Solubility
10 mM in DMSO
Smiles
O=C([C@H](C)[C@]1([H])O2)N[C@@]1([C@@H](O)C(C)C)C2=O
Molecular Formula
C10H15NO4
Molecular Weight
213.23
Precautions
H319
References & Citations
[1]Fenteany G, et al. A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A. 1994 Apr 12;91 (8) :3358-62.|[2]McCormack TA, et al. Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone. Biochemistry. 1998 May 26;37 (21) :7792-800.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
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