8β,9α-Dihydroxylindan-4 (5),7 (11) -dien-8alpha,12-olide
8β,9α-Dihydroxylindan-4 (5),7 (11) -dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4 (5),7 (11) -dien-8alpha,12-olide has inhibitory property on cell motility[1].
Product Specifications
CAS Number
956707-04-3
UNSPSC
12352005
Target
LIM Kinase (LIMK)
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8β-9α-dihydroxylindan-4-5-7-11-dien-8alpha-12-olide.html
Solubility
10 mM in DMSO
Smiles
CC([C@H]1C[C@H]1[C@]([C@@H]([C@](O2)3O)O)4C)=C4CC3=C(C)C2=O
Molecular Formula
C15H18O4
Molecular Weight
262.30
References & Citations
[1]Jianjiang Fu, et al. In vitro inhibitory properties of sesquiterpenes from Chloranthus serratus on cell motility via down-regulation of LIMK1 activation in human breast cancer. Phytomedicine. 2018 Oct 1;49:23-31.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
LIMK1
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