Encequidar (mesylate)

Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor.

Product Specifications

CAS Number

[849675-87-2]

Product Name Alternative

HM30181 (mesylate) ; HM30181A (mesylate)

UNSPSC

12352005

Hazard Statement

H317, H335

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HM30181_mesylate.html

Purity

99.82

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C2=CC=CC=C2O1)=O)NC3=CC(OC)=C(OC)C=C3C4=NN(C5=CC=C(CCN6CC7=C(C=C(OC)C(OC)=C7)CC6)C=C5)N=N4.CS(=O)(O)=O

Molecular Formula

C39H40N6O10S

Molecular Weight

784.83

Precautions

H317, H335

References & Citations

[1]Kim JC, et al. Effect of HM30181 mesylate salt-loaded microcapsules on the oral absorption of NSC 125973 as a novel P-glycoprotein inhibitor. Int J Pharm. 2016 Jun 15;506 (1-2) :93-101.|[2]Joo KM, et al. Response of brain specific microenvironment to P-glycoprotein inhibitor: an important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors. Int J Oncol. 2008 Oct;33 (4) :705-12.