VISTA-IN-3
VISTA-IN-3 (Compound A4) is a potent VISTA small molecule inhibitor with a KD value of 0.49 μM. VISTA-IN-3 can induce the release of IFN-γ cytokines. VISTA-IN-3 synergistically enhances anti-cancer activity with PD-L1 antibody[1].
Product Specifications
CAS Number
[2994662-45-0]
UNSPSC
12352005
Target
IFNAR
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vista-in-3.html
Purity
99.83
Solubility
DMSO : 6.25 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(NC2=NC(OC)=CC(CNCCO)=N2)=C1
Molecular Formula
C14H18N4O3
Molecular Weight
290.32
References & Citations
[1]Sun C, He Y, et al. Design, Synthesis, and Antitumor Activity Evaluation of Novel VISTA Small Molecule Inhibitors. J Med Chem. 2024 Feb 27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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