IDH1 Inhibitor 9
IDH1 Inhibitor 9 (compound 11S) is a potent IDH1 inhibitor with IC50 values of 124.4, 95.7 nM for IDH1 R132H, IDH1 R132C, respectively. IDH1 Inhibitor 9 induces apoptosis and cell cycle arrest at the S phase. IDH1 Inhibitor 9 shows anti-tumor activity[1].
Product Specifications
CAS Number
[3037967-71-5]
UNSPSC
12352005
Target
Apoptosis; Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/idh1-inhibitor-9.html
Smiles
OC1=CC(OC)=C(C/C=C(C)/C)C=C1C2=NC(N3CCNCC3)=NC(C4=CC=C(O)C=C4)=C2
Molecular Formula
C26H30N4O3
Molecular Weight
446.54
References & Citations
[1]Xu T, et al. Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study. Eur J Med Chem. 2024 Jun 17;275:116610.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1
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