IDH1 Inhibitor 9

IDH1 Inhibitor 9 (compound 11S) is a potent IDH1 inhibitor with IC50 values of 124.4, 95.7 nM for IDH1 R132H, IDH1 R132C, respectively. IDH1 Inhibitor 9 induces apoptosis and cell cycle arrest at the S phase. IDH1 Inhibitor 9 shows anti-tumor activity[1].

Product Specifications

CAS Number

[3037967-71-5]

UNSPSC

12352005

Target

Apoptosis; Isocitrate Dehydrogenase (IDH)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/idh1-inhibitor-9.html

Smiles

OC1=CC(OC)=C(C/C=C(C)/C)C=C1C2=NC(N3CCNCC3)=NC(C4=CC=C(O)C=C4)=C2

Molecular Formula

C26H30N4O3

Molecular Weight

446.54

References & Citations

[1]Xu T, et al. Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study. Eur J Med Chem. 2024 Jun 17;275:116610.