Arformoterol

Arformoterol ((R, R) -Formoterol), the (R, R) -enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD) [1][2].

Product Specifications

CAS Number

[67346-49-0]

Product Name Alternative

(R, R) -Formoterol

UNSPSC

12352005

Hazard Statement

H332, H351, H361, H370, H372

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/arformoterol.html

Purity

99.96

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC=C([C@@H](O)CN[C@H](C)CC2=CC=C(OC)C=C2)C=C1NC=O

Molecular Formula

C19H24N2O4

Molecular Weight

344.40

Precautions

H332, H351, H361, H370, H372

References & Citations

[1]Handley DA, et, al. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002;15 (2) :135-45.|[2]Cazzola M, et, al. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4 (2) :155-62.|[3]Song W, et, al. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am J Respir Cell Mol Biol. 2011 Jul;45 (1) :88-94.