NoxA1ds (TFA)
NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM) . NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors[1].
Product Specifications
UNSPSC
12352209
Target
NADPH Oxidase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/noxa1ds-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.CC(C)[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H]1N(CCC1)C([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C50H88N14O15.xC2HF3O2
Molecular Weight
1125.32 (free base)
References & Citations
[1]Ranayhossaini DJ, et al. Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J Biol Chem. 2013;288 (51) :36437-36450.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NOX1
Frequently Asked Questions
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