Collagen Type VI, Human

Collagen type VI is found as 5-10 nm diameter microfibrils (periodicity 100 nm) e.g. in placenta, skin, cartilage and cornea. Collagens consist of a family of highly specialized glycoproteins of which at least 16 genetically distinct types are known to date. The basal unit of a collagen molecule consists of a triple-helical structure formed by 3 alpha-chains. Predominant amino acids are glycine, proline and hydroxproline. Regularly also lysines and hydroxylysines occur, which are responsible for cross-linkage and glycosylation of the protein chains. Different composition of alpha-chains and different glycosylation contribute to the high variability of collagens in different tissues and organs. Human collagen type VI 100%, Human collagen type I, II, III, IV and V <0.1%; Human elastin and Human laminin <0.1%; Human fibronectin < 1% (RIA at 1:10.000 dilution).

*These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in Humans or animals.

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