STAT3-IN-38
STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM) . STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1) . STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells[1].
Product Specifications
CAS Number
3033049-16-7
UNSPSC
12352211
Target
Apoptosis; STAT; Survivin
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-38.html
Smiles
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(NCCC4=CC=CS4)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
Molecular Formula
C35H45NO3S
Molecular Weight
559.80
References & Citations
[1]Xu, et al. Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition. Journal of enzyme inhibition and medicinal chemistry. 2022, 37 (1), 236–251.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
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