Sarilumab
Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis[1][2].
Product Specifications
CAS Number
[1189541-98-7]
Product Name Alternative
Anti-Human IL6Rα, Human Antibody
UNSPSC
12352203
Target
Interleukin Related
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/sarilumab.html
Purity
99.36
Solubility
H2O
Smiles
[Sarilumab]
Molecular Weight
(144.12 kDa)
References & Citations
[1]McCarty D, et al. Efficacy and safety of sarilumab in patients with active rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2018;10 (3) :61-67.|[2]Xu C, et al. Population Pharmacokinetics of Sarilumab in Patients with Rheumatoid Arthritis. Clin Pharmacokinet. 2019;58 (11) :1455-1467.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Isoform
IL-6
Available Sizes
Curated Selection
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