I-TAC rabbit pAb

Disease: Expressed in a variety of skin disorders, including allergic contact dermatitis, lichen planus and mycosis fungoides. function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. induction: By interferon gamma and interferon beta. Induction by IFN-gamma is enhanced by TNF-alpha in monocytes, dermal fibroblasts and endothelial cells, and by IL-1 in astrocytes. mass spectrometry: PubMed: 10233762, online information: CXCL11 entry, similarity: Belongs to the intercrine alpha (chemokine CxC) family. tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.