HDAC-IN-72

HDAC-IN-72 (compound 7j) is the most potent HDAC1 (IC50=0.65 μM), HDAC2 (IC50=0.78 μM), HDAC3 (IC50=1.70 μM) inhibitor and antiproliferative compound. HDAC-IN-72 can be used for breast cancer research[1].

Product Specifications

CAS Number

[763066-77-9]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-72.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=C(C(NC2=CC=CC=C2N)=O)C=C1)C3=CC=C(C)C=C3

Molecular Formula

C22H21N3O2

Molecular Weight

359.42

References & Citations

[1]Cheshmazar N, et al. Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation[J]. Future Medicinal Chemistry, 2024 (0) .