KAN0438757
KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM[1].
Product Specifications
CAS Number
1451255-59-6
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kan0438757.html
Purity
99.41
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C(OCCO)C1=CC=C(NS(=O)(C2=CC(C3=CC(F)=CC=C3O)=CC=C2)=O)C=C1O
Molecular Formula
C21H18FNO7S
Molecular Weight
447.43
References & Citations
[1]Gustafsson NMS, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018 Sep 24;9 (1) :3872.|[2]De Oliveira T, et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. Cancers (Basel) . 2021 Feb 28;13 (5) :1011.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC404228 20 µg
Nucleostemin (GNL3) (NM_206826) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNUB1797-500 1x 500 µL
Histone H1 (Nuclear Marker) (r1415-1), 0.2mg/mL
Sign In for Pricing
View Details 
LC432009 20 µg
PARIS (ZNF746) (NM_001163474) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNC402312-500 1x 500 µL
SOX10 (Melanoma Marker) (rSOX10/1074), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details