Valecobulin (hydrochloride)

Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine proagent of S516 (HY-130233) and a vascular disrupting agent (VDA) . Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2].

Product Specifications

CAS Number

[1240321-53-2]

Product Name Alternative

CKD-516 (hydrochloride)

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/valecobulin-hydrochloride.html

Purity

98.46

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

CC(C)[C@H](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O.Cl

Molecular Formula

C26H29ClN6O5S

Molecular Weight

573.06

References & Citations

[1] Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53 (17) :6337-54.|[2]Joo I, et al. Intravoxel incoherent motion diffusion-weighted MR imaging for monitoring the therapeutic efficacy of the vascular disrupting agent CKD-516 in rabbit VX2 liver tumors. Radiology. 2014 Aug;272 (2) :417-26.