PARL-IN-1 (TFA)

PARL-IN-1 TFA is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy[1].

Product Specifications

UNSPSC

12352005

Target

Mitophagy; PINK1/Parkin

Type

Reference compound

Related Pathways

Autophagy; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/parl-in-1-tfa.html

Purity

95.01

Smiles

O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(C(NCCCCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F

Molecular Formula

C41H57F3N6O9

Molecular Weight

834.92

References & Citations

[1]Poláchová E, et, al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023 Jan 12;66 (1) :251-265.