PARL-IN-1 (TFA)
Product Specifications
UNSPSC Description
PARL-IN-1 TFA is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy[1].
Target Antigen
Mitophagy; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/parl-in-1-tfa.html
Purity
95.01
Smiles
O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(C(NCCCCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F
Molecular Weight
834.92
References & Citations
[1]Poláchová E, et, al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023 Jan 12;66(1):251-265.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152265A/PARL-IN-1-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152265A/
Clinical Information
Phase 2
Curated Selection
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