PARL-IN-1 (TFA)
PARL-IN-1 TFA is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy[1].
Product Specifications
UNSPSC
12352005
Target
Mitophagy; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/parl-in-1-tfa.html
Purity
95.01
Smiles
O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(C(NCCCCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F
Molecular Formula
C41H57F3N6O9
Molecular Weight
834.92
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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