SGC707
SGC707, a chemical probe, is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM) .
Product Specifications
CAS Number
1687736-54-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/SGC707.html
Purity
99.71
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=NC=CC3=C2
Molecular Formula
C16H18N4O2
Molecular Weight
298.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Kaniskan HÜ, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) . Angew Chem Int Ed Engl. 2015 Apr 20;54 (17) :5166-70.|[2]de Jong LM, et al. PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Sci Rep. 2022 Jan 10;12 (1) :483.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT3
Available Sizes
Frequently Asked Questions
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