SGC707

SGC707, a chemical probe, is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM) .

Product Specifications

CAS Number

[1687736-54-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SGC707.html

Purity

99.71

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=NC=CC3=C2

Molecular Formula

C16H18N4O2

Molecular Weight

298.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Kaniskan HÜ, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) . Angew Chem Int Ed Engl. 2015 Apr 20;54 (17) :5166-70.|[2]de Jong LM, et al. PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Sci Rep. 2022 Jan 10;12 (1) :483.