GSK 3 Inhibitor IX

GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β) /CDK1/CDK5, respectively.

Product Specifications

CAS Number

[667463-62-9]

Product Name Alternative

6-Bromoindirubin-3'-oxime; BIO; MLS 2052

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; CDK; GSK-3

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BIO.html

Purity

99.73

Solubility

DMSO : ≥ 23 mg/mL

Smiles

O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=CC(Br)=C4)=O

Molecular Formula

C16H10BrN3O2

Molecular Weight

356.17

Precautions

H315, H319

References & Citations

[1]Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66.|[2]Sato N, et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med. 2004 Jan;10 (1) :55-63. Epub 2003 Dec 21.|[3]Tseng AS, et al. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 2006 Sep;13 (9) :957-63.|[4]Liu L1, et al. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res. 2011 Jun 1;71 (11) :3972-9