GSK 3 Inhibitor IX
GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β) /CDK1/CDK5, respectively.
Product Specifications
CAS Number
667463-62-9
Product Name Alternative
6-Bromoindirubin-3'-oxime; BIO; MLS 2052
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; CDK; GSK-3
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BIO.html
Purity
99.73
Solubility
DMSO : ≥ 23 mg/mL
Smiles
O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=CC(Br)=C4)=O
Molecular Formula
C16H10BrN3O2
Molecular Weight
356.17
Precautions
H315, H319
References & Citations
[1]Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66.|[2]Sato N, et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med. 2004 Jan;10 (1) :55-63. Epub 2003 Dec 21.|[3]Tseng AS, et al. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 2006 Sep;13 (9) :957-63.|[4]Liu L1, et al. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res. 2011 Jun 1;71 (11) :3972-9
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
CDK1; CDK2; CDK4; CDK5; GSK-3α; GSK-3β
Available Sizes
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