Tau Peptide (275-305) (Repeat 2 domain)

Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's Tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein. Tau Peptide (275-305) specifically coordinates with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), which can induce their conformational changes and significantly promote their pathological accumulation. Tau Peptide (275-305) can be used to study the role of heavy metals in neurodegenerative diseases[1][2].

Product Specifications

CAS Number

[330456-25-2]

UNSPSC

12352209

Target

Tau Protein

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tau-peptide-275-305-repeat-2-domain.html

Purity

98.83

Solubility

DMSO : 12.5 mg/mL (adjust pH to 3 with 1 M HCl) |H2O : ≥ 25 mg/mL

Smiles

CC(C)[C@H](N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CN=CN1)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(NCC(NCC(NCC(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C139H239N43O45S

Molecular Weight

3264.71

References & Citations

[1]Dan-Jing Yang, et al. Mercury (II) promotes the in vitro aggregation of tau fragment corresponding to the second repeat of microtubule-binding domain: Coordination and conformational transition. Biopolymers. 2010 Dec;93 (12) :1100-7.|[2]Yang DJ, et al. Cooperative folding of tau peptide by coordination of group IIB metal cations during heparin-induced aggregation. Biometals. 2012 Apr;25 (2) :361-72.