ATX-II

ATX-II is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata) . ATX-II causes delayed inactivation of the Na+[1][2].

Product Specifications

CAS Number

[60748-45-0]

UNSPSC

12352209

Target

Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/atx-ii.html

Purity

97.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CN)N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N3[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]4CC(N)=O)=O)CC5=CNC=N5)=O)CC6=CNC7=CC=CC=C67)=O)=O)CO)=O)CCC3)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CCCCN)=O)=O)=O)C)=O)CC(C)C)=O)CC9=CNC%10=CC=CC=C9%10)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)=O)CO)=O)CC(C)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CO)=O)CCC2)=O)=O)CC(O)=O)=O)CO)=O)CC(O)=O)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N%11[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]%12CC%13=CNC%14=CC=CC=C%13%14)=O)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CCC%11)=O)=O)CC%15=CNC=N%15)=O)CCCCN)=O)CCCCN)=O)=O)CC(C)C)=O)CSSC[C@@H]8NC%12=O)=O)CCC1)=O)C(C)C

Molecular Formula

C213H323N63O61S6

Molecular Weight

4934.62

References & Citations

[1]Fletcher JE, et al. ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine. Anesthesiology. 1999 May;90 (5) :1294-301.|[2]Lu YY, et al. ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome. Eur J Clin Invest. 2012 Aug;42 (8) :823-31.