10074-G5
10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.
Product Specifications
CAS Number
413611-93-5
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Autophagy; c-Myc
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/10074-G5.html
Purity
99.63
Solubility
DMSO : ≥ 28 mg/mL
Smiles
O=[N+]([O-])C1=CC=C(NC2=CC=CC=C2C3=CC=CC=C3)C4=NON=C41
Molecular Formula
C18H12N4O3
Molecular Weight
332.31
Precautions
H301, H315, H319, H335
References & Citations
[1]Clausen DM, et al. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther. 2010 Dec;335 (3) :715-27.|[2]Chauhan J, et al. Discovery of methyl 4'-methyl-5- (7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) -[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization. ChemMedChem. 2014 Oct;9 (10) :2274-85.|[3]Yap JL, et al. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23 (1) :370-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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