Interleukin-21 (Human, Recombinant)

<strong>Interleukin-21 (Human, Recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2010308_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Interleukin-21 (Human, Recombinant) expressed in E. coli. This protein acts as a class 1 cytokine produced by activated CD4+ T cells. This protein stimulates T cells, B cells and NK cells, leading to enhanced proliferation and mature effector function._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuIL-21; Za11; IL21_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic_x000D_ potential. Nat Rev Drug Discov. 2014 May;13(5):379-95._x000D_ _x000D_ 2: Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M,_x000D_ Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K,_x000D_ Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, Nakaoka Y._x000D_ Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of_x000D_ pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015 May_x000D_ 19;112(20):E2677-86._x000D_ _x000D_ 3: Solaymani-Mohammadi S, Eckmann L, Singer SM. Interleukin (IL)-21 in_x000D_ Inflammation and Immunity During Parasitic Diseases. Front Cell Infect_x000D_ Microbiol. 2019 Dec 4;9:401._x000D_ _x000D_ 4: Tangye SG, Ma CS. Regulation of the germinal center and humoral immunity by_x000D_ interleukin-21. J Exp Med. 2020 Jan 6;217(1):e20191638._x000D_ _x000D_ 5: Long D, Chen Y, Wu H, Zhao M, Lu Q. Clinical significance and immunobiology_x000D_ of IL-21 in autoimmunity. J Autoimmun. 2019 May;99:1-14._x000D_ _x000D_ 6: Paidipally P, Tripathi D, Van A, Radhakrishnan RK, Dhiman R,_x000D_ Venkatasubramanian S, Devalraju KP, Tvinnereim AR, Valluri VL, Vankayalapati R._x000D_ Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium_x000D_ tuberculosis Infection. J Infect Dis. 2018 Mar 28;217(8):1323-1333._x000D_ _x000D_ 7: Vallières F, Durocher I, Girard D. Biological activities of interleukin_x000D_ (IL)-21 in human monocytes and macrophages. Cell Immunol. 2019 Mar;337:62-70._x000D_ _x000D_ 8: Khattar M, Baum CE, Schroder P, Breidenbach JD, Haller ST, Chen W, Stepkowski_x000D_ S. Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in_x000D_ murine heart allograft rejection. PLoS One. 2019 Nov 22;14(11):e0225624._x000D_ _x000D_ 9: Linnebacher A, Mayer P, Marnet N, Bergmann F, Herpel E, Revia S, Yin L, Liu_x000D_ L, Hackert T, Giese T, Herr I, Gaida MM. Interleukin 21 Receptor/Ligand_x000D_ Interaction Is Linked to Disease Progression in Pancreatic Cancer. Cells. 2019_x000D_ Sep 18;8(9):1104._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/11081504/">10: Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA,_x000D_ Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C,_x000D_ Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly_x000D_ K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching_x000D_ A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD,_x000D_ Foster D. Interleukin 21 and its receptor are involved in NK cell expansion and_x000D_ regulation of lymphocyte function. Nature. 2000 Nov 2;408(6808):57-63. </a>_x000D_ _x000D_ <strong>Products Related to Interleukin-21 (Human, Recombinant) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>