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C-Kit-IN-1

C-Kit-IN-1 is a potent inhibitor of c-Kit and c-Met with IC50s of <200 nM.

Product Specifications

CAS Number

[1225278-16-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

C-Kit; c-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c-Kit-IN-1.html

Purity

98.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1(CC1)C(NC2=CC=CC=C2)=O)NC3=CC(F)=C(OC4=CC=NC(C5=CN(C)N=C5)=C4)C=C3F

Molecular Formula

C26H21F2N5O3

Molecular Weight

489.47

Precautions

H315, H319, H335

References & Citations

[1]Daniel L. Flynn, et al. Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities. WO 2010051373 A1

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

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