Meclonazepam

Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect[1]. Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect[2].

Product Specifications

CAS Number

[58662-84-3]

Product Name Alternative

Ro 11-3128; Ro 11-3128/002

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/meclonazepam.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NC2=CC=C([N+]([O-])=O)C=C2C(C3=CC=CC=C3Cl)=N[C@H]1C

Molecular Formula

C16H12ClN3O3

Molecular Weight

329.74

Precautions

H302, H315, H319, H335

References & Citations

[1]T U Järbe, et al. Cueing effects of anxiolytic benzodiazepines (DZP and Ro 11-3128) : stereospecificity and antagonism by the convulsant benzodiazepine Ro 5-3663. Psychopharmacology (Berl) . 1988;94 (4) :501-6.|[2]L Pica-Mattoccia, et al. Praziquantel and the benzodiazepine Ro 11-3128 do not compete for the same binding sites in schistosomes. Parasitology. 2008 Jan;135 (Pt 1) :47-54.