Methoxyamine (hydrochloride)

Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2].

Product Specifications

CAS Number

[593-56-6]

Product Name Alternative

O-Methylhydroxylamine (hydrochloride)

UNSPSC

12352211

Hazard Statement

H290, H302+H312, H315, H317, H319, H351, H372, H410

Target

Apoptosis; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/methoxyamine-hydrochloride.html

Purity

99.11

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NOC.[H]Cl

Molecular Formula

CH6ClNO

Molecular Weight

83.52

Precautions

H290, H302+H312, H315, H317, H319, H351, H372, H410

References & Citations

[1]Sameer Agnihotri, et al. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discov. 2014 Oct;4 (10) :1198-213.|[2]Samideh Khoei, et al. Effects of resveratrol and methoxyamine on the radiosensitivity of iododeoxyuridine in U87MG glioblastoma cell line. Exp Biol Med (Maywood) . 2016 Jun;241 (11) :1229-36.