EXP3179
EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX) -2. EXP3179 exerts potent anti-inflammatory actions[1].
Product Specifications
CAS Number
114798-36-6
Product Name Alternative
Losartan Carboxaldehyde; DuP 167
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/exp3179.html
Purity
98.09
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
[H]N1N=NN=C1C2=CC=CC=C2C3=CC=C(C=C3)CN4C(C([H])=O)=C(N=C4CCCC)Cl
Molecular Formula
C22H21ClN6O
Molecular Weight
420.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Rossi GP. Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?. Hypertension. 2009;54 (4) :710-712.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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