EXP3179

EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX) -2. EXP3179 exerts potent anti-inflammatory actions[1].

Product Specifications

CAS Number

[114798-36-6]

Product Name Alternative

Losartan Carboxaldehyde; DuP 167

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/exp3179.html

Purity

98.09

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

[H]N1N=NN=C1C2=CC=CC=C2C3=CC=C(C=C3)CN4C(C([H])=O)=C(N=C4CCCC)Cl

Molecular Formula

C22H21ClN6O

Molecular Weight

420.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Rossi GP. Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?. Hypertension. 2009;54 (4) :710-712.