Autophagy inducer 5
Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; JNK; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/autophagy-inducer-5.html
Smiles
O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
Molecular Formula
C41H52N4O3
Molecular Weight
648.88
References & Citations
[1]Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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