H2L 5765834
H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively[1].
Product Specifications
CAS Number
420841-84-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/h2l-5765834.html
Concentration
10mM
Purity
98.66
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C(N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C2=O)=O)C=C1)O
Molecular Formula
C21H12N2O7
Molecular Weight
404.33
Precautions
H302, H315, H319
References & Citations
[1]Williams JR, et, al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19; 284 (25) : 17304-19.|[2]Bae GH, et, al. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8; 49 (12) : e407.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LPAR1; LPAR3; LPAR5
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
KN423673 1 Kit
Metabotropic Glutamate Receptor 4 (GRM4) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details 
BNC472540-100 1x 100 µL
SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) (SOX4/2540), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
LY400185 100 µg
HNF1 alpha (HNF1A) (NM_000545) Human Over-expression Lysate
Sign In for Pricing
View Details 