H2L 5765834

H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively[1].

Product Specifications

CAS Number

[420841-84-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/h2l-5765834.html

Concentration

10mM

Purity

98.66

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(C(N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C2=O)=O)C=C1)O

Molecular Formula

C21H12N2O7

Molecular Weight

404.33

Precautions

H302, H315, H319

References & Citations

[1]Williams JR, et, al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19; 284 (25) : 17304-19.|[2]Bae GH, et, al. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8; 49 (12) : e407.