S2/IAPinh
S2/IAPinh is a conjugate, which consist of an inhibitor for the apoptosis protein inhibitor (IAPinh) and a ligand for sigma 2 SW43. S2/IAPinh exhibits an anti-proliferative and apoptotic-inducing effect through degradation of the cellular inhibitor for apoptosis protein (clAP-1) [1].
Product Specifications
UNSPSC
12352005
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s2-iapinh.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1CC(N2CCCCCCCCCCNC(C)C(N[C@H](C(N3CCC[C@@]3([H])C4=NC(C(C5=CC=C(F)C=C5)=O)=CS4)=O)C6CCCCC6)=O)CCCC2C1)NC7=C(OC)C=CC(C)=C7.Cl.Cl
Molecular Formula
C52H75Cl2FN6O6S
Molecular Weight
1002.16
References & Citations
[1]Hagi T, et al., The novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer. Sci Rep. 2024 Mar 16;14 (1) :6373.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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