SHIP2-IN-1
SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 μM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
Product Specifications
CAS Number
2252247-80-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SHIP2-IN-1.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(Cl)C([C@@H](C)OC2=CN=CC(C3=CN=C(N)N=C3)=C2)=C(Cl)C=C1
Molecular Formula
C17H13Cl2FN4O
Molecular Weight
379.22
Precautions
H315, H319
References & Citations
[1]Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7077201 Inquire
Recombinant Rhodospirillum rubrum Prolipoprotein diacylglyceryl transferase (lgt), partial
Sign In for Pricing
View Details 