SHIP2-IN-1
SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 μM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
Product Specifications
CAS Number
2252247-80-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SHIP2-IN-1.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(Cl)C([C@@H](C)OC2=CN=CC(C3=CN=C(N)N=C3)=C2)=C(Cl)C=C1
Molecular Formula
C17H13Cl2FN4O
Molecular Weight
379.22
Precautions
H315, H319
References & Citations
[1]Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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