SHIP2-IN-1

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 μM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].

Product Specifications

CAS Number

[2252247-80-4]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SHIP2-IN-1.html

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(Cl)C([C@@H](C)OC2=CN=CC(C3=CN=C(N)N=C3)=C2)=C(Cl)C=C1

Molecular Formula

C17H13Cl2FN4O

Molecular Weight

379.22

Precautions

H315, H319

References & Citations

[1]Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.