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Liothyronine (sodium)

Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

Product Specifications

CAS Number

[55-06-1]

Product Name Alternative

Triiodothyronine (sodium) ; 3,3',5-Triiodo-L-thyronine (sodium) ; T3 (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/3,3_acute_,5-Triiodo-L-thyronine-sodium.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O

Molecular Formula

C15H11I3NNaO4

Molecular Weight

672.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94.|[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92.|[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20 (11) :3622-34.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Human Endogenous Metabolite

Citation 01

BioRxiv. 2024 November 15.|BMC Biol. 2025 Apr 24;23 (1) :107.|J Adv Res. 2025 Apr 19:S2090-1232 (25) 00273-5.|J Ethnopharmacol. 2022 Nov 15:298:115622.|JCI Insight. 2021 Jun 22;6 (12) :e142838.|Nat Cell Biol. 2025 Oct 15.|Sci Adv. 2024 Feb 9;10 (6) :eadk3931.|Acta Pharmacol Sin. 2024 May 24.|Adipocyte. 2022 Dec;11 (1) :84-98.|Adv Healthc Mater. 2025 Apr;14 (9) :e2404388.|Adv Sci (Weinh) . 2025 Nov 9:e08571.|Am J Physiol Endocrinol Metab. 2024 May 1;326 (5) :E696-E708.|bioRxiv. 2025 Oct 14.|Cell Death Discov. 2022 Apr 30;8 (1) :236.|Cell Metab. 2023 Nov 7;35 (11) :1915-1930.e8.|Cell Rep. 2024 Mar 18;43 (3) :113930.|Chem Eng J. 2024 Sep 15.|Drug Metab Dispos. 2025 Sep 23.|Environ Sci Technol. 2025 Mar 11;59 (9) :4530-4539.|Eur J Med Chem. 2024 Apr 5:269:116344.|Food Science and Human Wellness. 2023 Nov;12 (6) ;2061-2072.|J Hazard Mater. 2025 Mar 29:492:138085.|J Med Chem. 2022 Feb 10;65 (3) :2571-2592.|J Nutr Biochem. 2020 Apr;78:108335.|J Therm Biol. 2024 Jul 2:123:103906.|Methods Mol Biol. 2023:2683:103-111.|Mol Metab. 2024 Oct 29:102053.|Mol Metab. 2025 May:95:102125.|Nat Commun. 2023 Jun 2;14 (1) :3208.|Nat Commun. 2025 Aug 11;16 (1) :7414.|Patent. US20220389379A1.|Phytomedicine. 2025 Oct 11:148:157400.|Redox Biol. 2025 Sep:85:103751.|Sci Rep. 2024 Sep 2;14 (1) :20370.

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