Apelin-17 (human, bovine)

Apelin-17 (human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17 (human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02) . Apelin-17 (human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

Product Specifications

CAS Number

[217082-57-0]

UNSPSC

12352209

Target

Apelin Receptor (APJ) ; HIV

Type

Peptides

Related Pathways

Anti-infection; GPCR/G Protein

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/apelin-17-human-bovine.html

Purity

98.71

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

NCCCC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N3[C@@H](CCC3)C(N[C@@H](CCSC)C(N4[C@@H](CCC4)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C96H156N34O20S

Molecular Weight

2138.55

References & Citations

[1]Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251 (2) :471-476.|[2]Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84 (5) :1162-1172.|[3]Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV) . FEBS Lett. 2000;473 (1) :15-18.