Apelin-17 (human, bovine)
Apelin-17 (human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17 (human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02) . Apelin-17 (human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].
Product Specifications
CAS Number
217082-57-0
UNSPSC
12352209
Target
Apelin Receptor (APJ) ; HIV
Type
Peptides
Related Pathways
Anti-infection; GPCR/G Protein
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/apelin-17-human-bovine.html
Purity
98.71
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
NCCCC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N3[C@@H](CCC3)C(N[C@@H](CCSC)C(N4[C@@H](CCC4)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C96H156N34O20S
Molecular Weight
2138.55
References & Citations
[1]Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251 (2) :471-476.|[2]Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84 (5) :1162-1172.|[3]Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV) . FEBS Lett. 2000;473 (1) :15-18.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HIV-1; HIV-2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470460-100 1x 100 µL
CD44 Standard (156-3C11), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880177-500 1x 500 µL
CD50 (ICAM-3) (101-1D2), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040043-500 1x 500 µL
P21 / WAF1 (WA-1), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details