(±) -Epicatechin-13C3
(±) -Epicatechin-13C3 is the 13C labeled (±) -Epicatechin. (-) -Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-) -Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].
Product Specifications
CAS Number
1217780-28-3
UNSPSC
12352005
Target
COX; Endogenous Metabolite; Ferroptosis; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/racemic-epicatechin-13c3.html
Solubility
10 mM in DMSO
Smiles
O[13C@H]1[13C@@H](C2=CC(O)=C(C=C2)O)OC3=CC(O)=CC(O)=C3[13CH2]1
Molecular Formula
C12 13C3H14O6
Molecular Weight
293.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[3]Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-) -Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260.|[4]Nogueira L, et al. (-) -Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589 (Pt 18) :4615-31.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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