FXIa-IN-7

FXIa-IN-7 is a selective and orally bioavailable factor XIa inhibitor with an IC50 value of 0.4 nM.

Product Specifications

CAS Number

[2488952-56-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Factor Xa

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fxia-in-7.html

Purity

98.59

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC2=C1N(C[C@H](C3=CC(C(C)C)=CC(C4=CC=C(OC[C@H]5N)C5=C4)=C3)O)C=C2)O

Molecular Formula

C28H28N2O4

Molecular Weight

456.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Lorthiois E, et al. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem. 2020 Aug 13;63 (15) :8088-8113.