20S Proteasome-IN-5

20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the 20S Proteasome, with IC50 values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively[1].

Product Specifications

UNSPSC

12352209

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/20s-proteasome-in-5.html

Solubility

10 mM in DMSO

Smiles

CC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C([C@]1(CO1)C)=O)CC(C)C)=O)CC23)=O)=O)CC4=C(C([N+]([O-])=O)=CC=C4)OC5=CC3=C(C=C5)NC2=O)=O

Molecular Formula

C37H46N6O10

Molecular Weight

734.80

References & Citations

[1]Götz MG, et al. Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome. ACS Med Chem Lett. 2024 Mar 27;15 (4) :533-539.