20S Proteasome-IN-5
Product Specifications
UNSPSC Description
20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the 20S Proteasome, with IC50 values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively[1].
Target Antigen
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/20s-proteasome-in-5.html
Solubility
10 mM in DMSO
Smiles
CC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C([C@]1(CO1)C)=O)CC(C)C)=O)CC23)=O)=O)CC4=C(C([N+]([O-])=O)=CC=C4)OC5=CC3=C(C=C5)NC2=O)=O
Molecular Weight
734.80
References & Citations
[1]Götz MG, et al. Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome. ACS Med Chem Lett. 2024 Mar 27;15(4):533-539.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158150/20S-Proteasome-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158150/
Clinical Information
No Development Reported
Curated Selection
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