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20 (R) -Ginsenoside Rh2 (Standard)

20 (R) -Ginsenoside Rh2 (Standard) is the analytical standard of 20 (R) -Ginsenoside Rh2. This product is intended for research and analytical applications. 20 (R) -Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20 (R) -Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20 (R) -Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20 (R) -Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20 (R) -Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20 (R) -Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect.

Product Specifications

CAS Number

112246-15-8

UNSPSC

12352005

Target

Apoptosis; HSV; MMP; Reference Standards

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/20-r-ginsenoside-rh2-standard.html

Smiles

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1O[C@H]2CC[C@]3(C)[C@@]4([H])C[C@@H](O)[C@@H]5[C@@H]([C@](C)(O)CC/C=C(C)\C)CC[C@](C)5[C@@](C)4CC[C@@]3([H])C2(C)C

Molecular Formula

C36H62O8

Molecular Weight

622.87

References & Citations

[1]Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20 (R) -ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65 (2) :310-6.|[2]Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34 (2) :331-40.|[3]Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26 (10) :2280-8.|[4]Kang S, et al. Antiviral activity of 20 (R) -ginsenoside Rh2 against murine gammaherpesvirus. J Ginseng Res. 2017 Oct;41 (4) :496-502.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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