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Rabbit anti Human Calcium Channel

Product Specifications

Background

Heterologous expression studies have shown that the activity of voltage-gated Ca2+ channels is regulated by their beta subunits in a beta subunit isoform-specific manner. Our data show that all four beta subunit isoforms associate with L-type Ca2+ channels in mammalian brain. This beta subunit heterogeneity may play an important role for the fine tuning of L-type channel function and modulation in neurons.

UniProt

Q5VVH1

Host

Rabbit

Species Reactivity

Human

Isotype

IgG

Conjugation

Unconjugated

Type

Polyclonal Antibody

Source

Rabbits were immunized with a synthetic peptide derived from the rat beta2 calcium channel conjugated to KLH.

Applications

WB

Field of Research

Signal Transduction

Purification Method

Ammonium Sulfate Precipitation

Assay Principle

This antibody can be used for Western blotting (5-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided as solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1. Perez-Reyes,Eet.al 'Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.' J. Biol. Chem. 1992, 267, 1792-1797

Shipping Conditions

Ambient Temperature, freeze upon arrival

Storage Conditions

Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

Functional Analysis

WB

CAS Number

9007-83-4

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