AR-C67085

AR-C67085 (PSB 0413; FPL 67085) is a potent platelet P2T receptor antagonist with an pIC50 value of 8.60. AR-C67085 inhibits ADP-induced platelet aggregation[1][2].

Product Specifications

CAS Number

[164992-25-0]

Product Name Alternative

AR-C67085MX; PSB 0413; FPL 67085

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ar-c67085.html

Smiles

NC1=C2N=CN([C@@H]3O[C@H](OP(OP(C(P(O)(O)=O)(Cl)Cl)(O)=O)(OC)=O)[C@@H](O)[C@H]3O)C2=NC(SCCC)=N1

Molecular Formula

C14H22Cl2N5O12P3S

Molecular Weight

648.24

References & Citations

[1]Humphries RG, et al. A novel series of P2T purinoceptor antagonists: definition of the role of ADP in arterial thrombosis. Trends Pharmacol Sci. 1995 Jun;16 (6) :179-81.|[2]Ingall AH, et al. Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy. J Med Chem. 1999 Jan 28;42 (2) :213-20.