Nicardipine

Nicardipine (YC-93 free base) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure[1].

Product Specifications

CAS Number

[55985-32-5]

Product Name Alternative

YC-93 (free base)

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Nicardipine.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)NC(C)=C(C(OCCN(C)CC2=CC=CC=C2)=O)C1C3=CC=CC([N+]([O-])=O)=C3)OC

Molecular Formula

C26H29N3O6

Molecular Weight

479.52

Precautions

H315, H319, H320

References & Citations

[1]Charnet P, et al. Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers. Fundam Clin Pharmacol. 1987;1 (6) :413-31.|[2]R Stamatiou, et al. The dihydropyridine calcium antagonist nicardipine reduces aortic smooth muscle cell viability, proliferation and migration. Cardiovascular Research, 2018 Apr,114 (1) :S43.|[3]Sherrin H. Baky. Nic ardipine Hydrochloride.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Biosci Rep. 2019 Jul 2;39 (7) :BSR20190516.|Talanta. 2024 Jul 1:274:125947.|Int J Clin Exp Med. 2019;12 (5) :5184-5190.|J Dig Dis. 2025 Jan-Feb;26 (1-2) :62-73.|Research Square Preprint. 2023 Jul 21.