13-Methylberberine (chloride)

13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS[1][2][3].

Product Specifications

CAS Number

[54260-72-9]

Product Name Alternative

13-Methylberberinium (chloride)

UNSPSC

12352005

Hazard Statement

H301, H315

Target

Interleukin Related

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/13-methylberberine-chloride.html

Purity

99.16

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OCO5)=C5C=C4CC3.[Cl-]

Molecular Formula

C21H20ClNO4

Molecular Weight

385.84

Precautions

H301, H315

References & Citations

[1]Chow YL, et al. 13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells. Sci Rep. 2016 Dec 5;6:38129.|[2]Iwasa K, et al. In vitro cytotoxicity of the protoberberine-type alkaloids. J Nat Prod. 2001 Jul;64 (7) :896-8.|[3]Lee DU, et al. Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages. Life Sci. 2003 Aug 1;73 (11) :1401-12.