JHD205
JHD205 is a CDK4/6 inhibitor that induces apoptosis and DNA damage. JHD205 inhibits DNA repair by upregulating Caspase3 and p-H2AX. JHD205 has superior potency to Abemaciclib in a xenograft chick embryo breast cancer model.[1].
Product Specifications
UNSPSC
12352211
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jhd205.html
Smiles
COC1=CC(N2CCC(CC2)N3CCN(CC3)C)=CC=C1NC4=NC(C5=CC(F)=C6C(N(C(C)=N6)C(C)C)=C5)=C(C=N4)F
Molecular Formula
C32H40F2N8O
Molecular Weight
590.71
References & Citations
[1]Ji J, et al. JHD205, A Novel Abemaciclib Derivative, Exerts Antitumor Effects on Breast Cancer by CDK4/6. Anticancer Agents Med Chem. 2024;24 (6) :400-411.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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