AMG-1694
AMG-1694 is a potent glucokinase-glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].
Product Specifications
CAS Number
1361217-07-3
UNSPSC
12352005
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/amg-1694.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@](O)(C1=CC=C(N2[C@@H](CN3[C@@H](C)COCC3)CN(S(=O)(C4=CC=CS4)=O)CC2)C=C1)C(F)(F)F
Molecular Formula
C23H30F3N3O4S2
Molecular Weight
533.63
References & Citations
[1]Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504 (7480) :437-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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