ChemR23-IN-1

ChemR23-IN-1 (compound 2) is a ChemR23 inhibitor with IC50s of 38 nM and 100 nM for human and mouse ChemR23, respectively. ChemR23-IN-1 inhibits chemotaxis of CAL-1 triggered by Chemerin in vitro[1].

Product Specifications

CAS Number

[2378640-10-7]

UNSPSC

12352005

Target

Chemerin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/chemr23-in-1.html

Purity

98.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](N(CCCC)C1=NC2=CC(C(NC)=O)=CC=C2O1)C3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3

Molecular Formula

C28H29N7O2

Molecular Weight

495.58

References & Citations

[1]Takamichi Imaizumi, et al. The design, synthesis and evaluation of 2-aminobenzoxazole analogues as potent and orally efficacious ChemR23 inhibitors. Bioorg Med Chem. 2020 Sep 1;28 (17) :115622.