3'-O- (t-Butyldimethylsilyl) -2'-deoxy-2'-fluorouridine
3'-O- (t-Butyldimethylsilyl) -2'-deoxy-2'-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[1445379-59-8]
Product Name Alternative
2'-Deoxy-3'-O-[ (1,1-dimethylethyl) dimethylsilyl]-2'-fluorouridine
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-o-t-butyldimethylsilyl-2-deoxy-2-fluorouridine.html
Purity
91.46
Solubility
10 mM in DMSO
Smiles
F[C@@H]1[C@H](O[Si](C)(C(C)(C)C)C)[C@@H](CO)O[C@H]1N2C(NC(C=C2)=O)=O
Molecular Formula
C15H25FN2O5Si
Molecular Weight
360.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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