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(Rac) -Hesperetin (Standard)

(Rac) -Hesperetin (Standard) is the analytical standard of (Rac) -Hesperetin. This product is intended for research and analytical applications. (Rac) -Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor[1][2][3][4].

Product Specifications

CAS Number

69097-99-0

UNSPSC

12352005

Target

Apoptosis; Autophagy; Bcl-2 Family; NF-κB; p38 MAPK; Reactive Oxygen Species (ROS) ; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-hesperetin-standard.html

Smiles

O=C1CC(C2=CC=C(OC)C(O)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C16H14O6

Molecular Weight

302.28

References & Citations

[1]Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964|[2]Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39 (12) :2052-2059.|[3]Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301|[4]Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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