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GLP-1 (9-36) amide (TFA)

GLP-1 (9-36) amide TFA is a major metabolite of glucagon-like peptide-1- (7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4) . GLP-1 (9-36) amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor[1][2].

Product Specifications

UNSPSC

12352209

Target

GCGR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glp-1-9-36-amide-tfa.html

Purity

98.61

Solubility

DMSO : ≥ 2 mg/mL

Smiles

N=C(N)NCCC[C@@H](C(N)=O)NC(CNC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](N)CCC(O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C140H214N36O43.xC2HF3O2

Molecular Weight

3089.41 (free base)

References & Citations

[1]Knudsen LB, et al. Glucagon-like peptide-1- (9-36) amide is a major metabolite of glucagon-like peptide-1- (7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol. 1996;318 (2-3) :429-435.|[2]Elahi D, et al. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring) . 2008;16 (7) :1501-1509.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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